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| Dwayne Johnson | Krypto | |
| Kevin Hart | Ace | |
| Kate McKinnon | Lulu | |
| John Krasinski | Superman | |
| Vanessa Bayer | PB | |
| Natasha Lyonne | Merton | |
| Diego Luna | Chip | |
| Marc Maron | Lex Luthor | |
| Keanu Reeves | Batman | |
| Thomas Middleditch | Keith (aka Ice Guinea Pig) | |
| Ben Schwartz | Mark (aka Fire Guinea Pig) | |
| Olivia Wilde | Lois Lane | |
| Maya Erskine | Mercy Graves | |
| Yvette Nicole Brown | Patty | |
| Jameela Jamil | Wonder Woman |
| Director |
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| Producer |
Allison Abbate
Glenn Ficarra |
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| Writer |
Jared Stern
John Whittington |
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| Musician |
Steve Jablonsky
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When Superman and the rest of the Justice League are kidnapped, Krypto the Super-Dog must convince a rag-tag shelter pack - Ace the hound, PB the potbellied pig, Merton the turtle and Chip the squirrel - to master their own newfound powers and help him rescue the superheroes. |
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