The Black Hand are in pursuit of Anna Fulford and Murdoch's son. An Asian family is in turmoil after their daughter was murdered at the hands of her Caucasian husband. George Crabtree has been kidnapped by two deranged twin sisters.

Dr. Ogden proceeds with an unorthodox operation. Murdoch must outwit the Black Hand and return his son to Anna Fulford. George needs to break away from his captors. The real family member missing from an Asian family is determined.

Murdoch pursues former Inspector Giles after he escapes from prison to vindicate a murderer.

When their train derails, Ogden and Brackenridge suspect it was sabotage to hide a murder.

Murdoch investigates the murder of a ladies' man and Crabtree's aunt is the prime suspect.

At Halloween, Murdoch pursues a killer dressed as a clown who is terrorizing young couples.

To solve an inmate's murder, Murdoch sends Ogden undercover at a woman's reformatory.

While investigating a murder at a party, Murdoch and Brackenreid inadvertently discover spy Terrance Meyers' hidden civilian life.

While Det. Murdoch deals with the irritating Newsomes caught in a byzantine kidnapping situation, Julia must decide on her response to her former hospital blacklisting her.

Murdoch believes that the murder of a nasty, satirical cartoonist has links to city politics.

Murdoch and company's Christmas at an idyllic country estate turns deadly.

Murdoch investigates the suspicious death of a stage manager after a going away party for Mary Pickford.

When Detective Murdoch investigates the mysterious death of a colleague of Sigmund Freud, he receives an unexpected psychoanalysis from him

Murdoch arrests a man for trying to kill a woman who he claims is a witch, shortly after he dies mysteriously while in custody

Murdoch's son Harry is visiting from boarding school when Julia and William are abducted by a vengeful foe

A charity basketball game turns grim for Murdoch and his colleagues when a friend of the game's inventor is murdered

Violet Hart investigates when a protester dies at an event for Black people's rights

Murdoch investigates when a Japanese spy is found dead in a Korean family's cellar

A vagrant camp is opposite a house where a murder took place, hence the family suspect one of those homeless people committed the murder. Murdoch investigates the robbery and murder and other facts come to light.

Murdoch has to investigate after a murder is transmitted over James Pendrick's new invention.

Murdoch investigates the death of a musician whose murder was narrated in a blues song

When Crabtree's mentally-deranged kidnapper, Amelia, turns herself in, he braces for trouble.

When a man resembling Murdoch is shot, he must find the killer before the killer finds him.

With his family in hiding, Murdoch tries to discover who is behind attempts on their lives.