A wealthy backer asks the Dollhouse for help when his daughter is kidnapped. They send Echo to negotiate the release. One of the memory imprints used to prepare Echo for the mission causes some complications.

A man requests Echo as his companion on a camping trip. But his true intentions are far more deadly. More back story on the Dollhouse, and Boyd's first encounter with Echo.

Echo is programed for her next assignment to be a backup singer to protect a wealthy pop star, named Rayana, whose manager hires Dollhouse to protect his top client from an obsessed fan out to kill her. Newcomer active Sierra is also programed to be the Australian winner of the "Number One Fan Contest" to assist Echo to flush out the stalker. Meanwhile, Agent Ballard's investigation to find Caroline/Echo in order to link her to Dollhouse takes a turn for the worse when his Russian contact, Lubov, turns out to be an active for the Dollhouse and sets him up to be killed by Russian thugs of no relation to the matter he is investigating.

Echo's engagement to steal some art starts to go bad when she and others in her crew get locked in the vault. When Echo is wiped remotely, the Dollhouse must figure a way to get her out.

Echo is programed to go under cover as a blind woman at religious cult in Arizona after a corrupt senator recruits Dollhouse to assist the ATF in the breakup of the cult. But with Boyd watching from a distance, he soon learns that the Jonas Sparrow cult may be more difficult to handle, and the ATF agent in charge has an ulterior motive... as does Dominic when the situation takes a turn for the worse. Meanwhile, Agent Ballard continues his relentless quest to look for Echo while his neighbor, Mellie, continues to harbor a crush on him. Also, Topher and Dr. Saunders monitor Victor when he begins exhibiting primordial behavior whenever he's around Sierra.

Ballard gets a lead on a possible Dollhouse client and he finds more than he expected. Meanwhile at the Dollhouse, an active is being abused, possibly by another active.

Rossum Corporation asks the Dollhouse to send a large contingent of actives to a college campus to retrieve an experimental memory drug. The drug brings out suppressed memories which affect everyone, including the actives. Echo's origins are revealed.

The Dollhouse's worst fears are realized as several actives awaken and remember some of their past lives and try to escape from the Dollhouse.

DeWitt leaves Dominic in charge of the Dollhouse when she has to leave for a short period. Topher finds a chip in the imprint chair which has been used by other agencies to alter the programming on the actives. As the Dollhouse looks for the spy within, Ballard learns more about the Dollhouse.

Echo is imprinted with the memories of a deceased person, who wants to solve her own murder. Ballard gets digs deeper into Mellie's past. Topher needs an active to help him with his security check.

Echo helps a troubled youth. Ballard finally locates the Dollhouse. He locates someone who designed the Dollhouse, now he's closer than ever to rescuing Caroline.

Alpha has taken Echo. More secrets of the Dollhouse are revealed. Ballard must work with the Dollhouse to stop Alpha, if he wants to save Caroline.

In the future, the imprinting technology is rampant. A few people stumble on the Dollhouse.

It’s 2019 and the Dollhouse technology has been abused, causing the world to fall into a post-apocalyptic state.