Detective Murdoch and Inspector Brackenreid are aboard the SS Keewatin after the owner, Clarence MacFarlane, receives what he believes is a threat. The Keewatin is about to depart from Toronto on its maiden voyage destined for Rochester, N.Y. and Murdoch thinks they should stay on board, especially after he sees that Julia is one of the invited guests. Their presence proves useful after MacFarlane's daughter Amy, who is engaged to her father's chief financial officer Owen Mathers, falls overboard and is nowhere to be found. As Murdoch investigates he finds there is a real threat against the Keewatin and the true facts behind Amy's disappearance.

Detective Murdoch investigates the sudden death of bicycle racer Joe Fenton. Murdoch was himself a participant in the race trying out his newfangled gear shifting device but Fenton was the favorite having won several recent races. Fenton's manager, Chippy Blackburn, was seen giving him a potion and they suspect he may be may be fixing races. Dr. Grace however is having considerable difficulty finding a cause of death and with Dr. Ogden's assistance performs her first brain bisection.

Detective Murdoch and many others attend a special showing of a film that will also include sound. The man behind the scheme is James Pendrick and his main competitor, Thomas Edison, is also present for the showing. The film includes a scene where a shot is fired but when the lights come up, one of the patrons, Pendrick's principal investor, has been shot in the head.

Murdoch finds his investigation into a nanny's disappearance assisted by the man who considers himself the real Sherlock Holmes.

A man who appears to have returned from the dead is the prime suspect in his wife's murder.

Detective Murdoch investigates the death of one of Dr. Julia Ogden’s phobia patients, but can Murdoch overcome his own phobia to solve the case?

Detective Murdoch investigates the death of Katie Buchanan who is found dead at the beach, on a hot summer's day, by her friend Elaine Lawson. Both were entrants in a beauty pageant known as the Miss Purity competition, to select the new face of Alexander soap. Dr. Ogden, who is spending her day off at the beach finds what appears to be a large animal bite on the woman's torso. Katie's boyfriend, James Bennett, had recently left her for another competitor, Marie Nicholson and becomes the prime suspect. Inspector Brackenreid however is certain he saw a monster in Lake Ontario and Murdoch is skeptical until he too sees a creature in the water. Constable Crabtree is dismissive of any suggestion that there might be a monster in the water and pursues a more realistic line of inquiry.

Detective Murdoch investigates the death of Peter Farrelly who had a loud altercation with someone the night before his body was found. Dr. Grace determines he was beaten to death. She also found chloral hydrate in his system - a bottle of which they found in the victim's luggage. They believe both the victim and his killer are from Newfoundland and so Murdoch and Crabtree head off to St. John's in the hopes of finding the suspected killer Ezekiel Farrelly. Crabtree was actually raised in St. John's by several aunts who, it turns out, have an interesting occupation. The solution to murder lies with finding an old pirate treasure map.

Detective Murdoch, Inspector Brackenreid, Dr. Ogden and several others are transporting serial killer James Gillies to the prison in Kingston, Ontario where he is scheduled to be executed the next day. It creates a bit of a stir among the passengers when they learn who is being transported. Among them are Aaron Rauls, a late arrival on the train and Nathaniel Henry. Both come under suspicion when the police find a dead man, Dennis Bolton who was released from the Don jail just a week ago. There's no direct connection between Bolton and Gillies but both were in the same jail at the same time. As tensions rise, it becomes evident that Gillies has arranged for several ex-convicts to be on the train - all part of his plan to escape.

Detective Murdoch investigates the murder of Nathan Peters, a jazz musician and renowned band-leader, who was found dead at the docks. His group, the Jubilee Singers, was performing nearby and his wife had already reported him missing. Dr. Emily Grace determines that he died in the early hours of the morning from a blow to the head causing a subdural hemorrhage. The evidence in the case begins to point to one of the Jubilee Singers as the perpetrator. Much to George Crabtree's chagrin, Emily seems to have taken an interest in the roguish Leslie Garland. Julia meanwhile feels that a huge weight has been taken off her shoulders now that James Gillian is dead.

Crabtree insists that a string of robberies is caused by a species of mole people.

After a death-bed murder confession leads to a body, Murdoch suspects the true killer is still out there.

Murdoch orchestrates an elaborate sting when a past suspect returns with a deadly con.

Julia and Emily go to a bachelorette party; Murdoch and the boys get involved in a high stakes curling match.

The assassination of U.S. President McKinley in Buffalo prompts a roundup of Canada’s anarchists, landing Murdoch in the middle of a web of international espionage and intrigue.

When a Chinese dignitary visiting Toronto is poisoned, Crabtree teams up with the prime suspect – who he believes to be innocent – in order to track down the real killer.

A local industrialist is tied to the top of a telephone pole with a noise-activated bomb strapped to his chest. While Murdoch and his colleagues deal with the dilemma, Mayor Clarkson orders nearby businesses to be shut down to minimise sound pollution. However, the politician finds himself the criminal's next target.

When Julia Ogden's father passes away, she uncovers an unexpected truth behind his death - and his life. Meanwhile, Brackenreid must take over for Murdoch in the investigation of a murder amongst a group of geniuses.